diagenode
Diagenode, a Hologic company, is a global leader in providing complete solutions for epigenetics research, biological sample preparation, and diagnostic assays. Specialising in tools such as the Bioruptor® shearing and IP-Star® automation systems, Diagenode offers high-quality reagents, antibodies, and services for DNA methylation, ChIP, and NGS workflows. The company focuses on innovation, with its products used in cutting-edge research across the life sciences.

Authorised dealer for:

UK only

10/04/2024

Bioruptor Pico 2 DNA, RNA, and chromatin shearing sonicator from Wolflabs

Product Update

Introduction
Bioruptor Pico 2 DNA, RNA, and chromatin shearing sonicator from Wolflabs.
Diagenode’s Bioruptor uses state-of-the-art shearing device to disrupt, disperse, or shear a variety of sample types for biological, chemical, pharmaceutical, and industrial applications. It is the standard for DNA and RNA shearing, chromatin shearing, cell and tissue disruption, FFPE DNA extraction, DNA methylation studies and tissue RNA extraction.

Features and benefits
- Simultaneous sonication of 6 - 16 samples
- Ultra-low volumes of 20 μl to larger samples of up to 2 ml
- Easy and Advanced modes give both beginners and experienced users just the right level of control
- Cooling system with integrated valve to guarantee the automatic temperature control of the bath during the full shearing process

Product Category: Sonicators - DNA, RNA and Chromatin Shearing

Manufacturer: Diagenode

06/02/2023

Diagenode Megaruptor 3 searing sonicator from Wolflabs

Product Update

Introduction
Diagenode Megaruptor 3 searing sonicator from Wolflabs.

Features and benefits
- Processes 1 to 8 samples simultaneously
- Operates without user input and is easily tuneable to between 5 and 100 kb
- Ergonomic and space-efficient
- Safe from contamination and clogs, uses optimised consumables
- Provides the tight fragment distribution you need

Product Category: Sonicators - DNA, RNA and Chromatin Shearing

Manufacturer: Diagenode

17/07/2019

New Diagenode DNA, RNA and chromatin shearing sonicator from Wolflabs

Product Update

Inroduction
New Bioruptor Pico DNA, RNA and chromatin shearing sonicator from Diagenode has been added. 

Features and benefits
- All-in-one shearing solution.
- Small, light, and easy to use.
- Temperature-controlled.

Product Category: Sonicators - DNA, RNA and Chromatin Shearing

Manufacturer: Diagenode

26/05/2016

Diagenode bioruptor sonicators from Wolflabs

Product Update

Introduction
Diagenode’s Bioruptor uses state-of-the-art ultrasound technology to disrupt, disperse, or shear a variety of sample types for biological, chemical, pharmaceutical, and industrial applications. The Bioruptor is widely used in biological settings and has proven success for efficient, reproducible sonication required for applications such as DNA and RNA shearing, chromatin shearing, cell and tissue disruption, DNA methylation studies and tissue RNA extraction. Researchers have confirmed the Bioruptor as an optimal shearing system, surpassing industry standards with high yields of superior quality material, as exemplified by over 1000 publications.

Features and benefits
- Unsurpassed quality, consistency, and efficiency
- Closed tube format prevents cross-contamination and aerosol formation
- Variable power range efficiently and evenly disrupts samples
- Unique cooling system retains integrity of biological complexes
- Gentle ultrasound method preserves samples
- Sample rotation of tubes in sonication bath ensures shearing and lysis consistency
- Validated applications: Chromatin Immunoprecipitation (ChIP), Library Preparation for Next-Generation Sequencing, Methylated DNA Immunoprecipitation (MeDIP), MethylCap Assay (Methylbinding domain protein), Protein and Tissue RNA extraction
- Control over DNA fragment size range as distinct fragment size ranges may be required for specific applications. The Bioruptor can easily be controlled by modifying sonication duration for the desired fragmentation range
- Compatibility with existing lab workflows: Uses standard microfuge and conical tubes
- Ease of use: Easy set-up, operation, control parameters, and maintenance ensures success
- High-throughput capability: Allows parallel processing of up to 12 samples
- Scaling ability: Interchangeable sample holders allow for microliter to milliliter quantities
- Application flexibility: Efficient ACT (Adaptive Cavitation Technique) ultrasound technology enables high yields and reproducibility across biological, chemical, pharmaceutical, and industrial applications

Product Category: Sonicators - DNA, RNA and Chromatin Shearing

Manufacturer: Diagenode

Sonicators - Diagenode

(From left to right: UCD-200(Standard), UCD-300(Next Gen), UCD-400(Twin), UCD-500(XL))

Diagenode’s Bioruptor® Sonicator uses state-of-the-art ultrasound technology to disrupt, disperse, or shear a variety of sample types for biological, chemical, pharmaceutical, and industrial applications. The Bioruptor® Sonicator is widely used in biological settings and has proven success for efficient, reproducible sonication required for applications such as DNA/chromatin shearing, cell lysis, cell poration, and protein extraction. Researchers have confirmed the Bioruptor® Sonicator as an optimal shearing system, surpassing industry standards with high yields of superior quality material, as exemplified by over 200 publications.

Features and benefits of the Bioruptor® Sonicator

•The Bioruptor® Sonicator provides: Unsurpassed quality, consistency, and efficiency
– Closed tube format prevents cross-contamination and aerosol formation
– Variable power range efficiently and evenly disrupts samples
– Unique cooling system retains integrity of biological complexes
–Gentle ultrasound method preserves samples
– Sample rotation of tubes in water bath ensures shearing and lysis consistency

•Compatibility with existing lab workflows: Uses standard microfuge and conical tubes.
•Ease of use: Easy set-up, operation, control parameters, and maintenance ensures success.
•High-throughput capability: Allows parallel processing of up to 48 samples.
•Scaling ability: Interchangeable sample holders allow for microliter to milliliter quantities.
•Application flexibility: Efficient ultrasound technology enables high yields and reproducibility across biological, chemical, pharmaceutical, and industrial applications.

Technical Information

Model: UCD-200 UCD-300 UCD-400 UCD-500
Control unit dimensions mm (HxWxD): 195 x 150 x 300 195 x 150 x 300 195 x 150 x 300 160 x 400 x 260
Sonication Unit dimensions (HxWxD): 300x 117 x 190 150 x 350 x 260 150 x 350 x 260 280 x 320 x 180
Noise reduction box dimensions (HxWxD): 360 x 200 x 260 520 x 350 x 350 360 x 200 x 260 520 x 400 x 300
Sound proofing box: Plastic Metal Metal Metal
Output power: 320W 320W 320W 320W
Operating frequency: 20KHz 20KHz 20KHz 20KHz
Input power: 100V 100V 230V 240V
Timer & controls: Analogue timer Digital timer & controls Digital timer & controls Digital timer & controls
Min Volume: 0.5ml 0.5ml 0.5ml 0.5ml
Max Volume: 50ml 50ml 50ml 50ml
Water bath volume: 800cc 800cc 800cc 1800cc
Weight: 22.6kg 30kg 30kg 32.5kg

 

Diagenode Bioruptor Sonicator UCD-200

Bioruptor uses a unique system to uniformly process multiple samples simultaneously in sealed tubes of 0.5ml to 50ml capacity

  • Up to 12 tubes simultaneously

  • Analog Timer

  • Plastic noise reduction box

Advantages

  • Better reproducibility

  • Higher throughput

  • Validated protocols

  • Hundreds of publications

Applications for Bioruptor

  • Shearing (Chromatin & DNA)

  • Cleavage

  • Catalysis

  • Sonochemistry

  • Emulsification

  • Extraction

  • Dissolution

  • Disaggregation

  • Homogenization

  • Mixing

  • Synthesis

  • Cell lysing

  • Microencapsulation

  • Hydrolization

  • Degassing

  • Cleaning

Specification

Product Codes

 UCD-200TM /UCD-200FT / UCD-200TO
Ultrasonic wave frequency 20kHz
Ultrasonic wave output power 160, 200, 320W (switchable)
Power supply 100V, 50/60Hz, 4.2A
Transformer 220/100V dimensions 170(W) x 130(D) x 140(H) mm
Control unit dimensions 150(W) x 300(D) x 195(H) mm
Sonication Unit dimensions 117(W) x 190(D) x 300(H) mm
Noise reduction box dimensions 200(W) x 260(D) x 360(H) mm
Waterbath volume 800cc
Total timer Max 15min. Analogic
Interval timer On Cycle 0-60 sec. or min.
Off Cycle 0-60 sec. or min.
Attachment unit Available for 0.5 - 1.5 -10 - 15 & 50ml tubes
Number of samples to be processed simultaneously 0.5 ml 1.5 ml 10 ml 15ml 50 ml

12

6

6

6

3
Total weight 22.6Kg

Accessories

Soundproof Box BioBox-200 for use with Bioruptor & Bioruptor next gen UCD-200
Attachment for 0.5ml Micro Tube + Gear plate for use with Bioruptor & Bioruptor next gen UCD-pack 0.5
Attachment for 1.5ml Micro Tube + Gear plate for use with Bioruptor & Bioruptor next gen UCD-pack 1.5
Adaptors for 10ml tube (6pc) + Gear plate for use with Bioruptor & Bioruptor next gen UCD-pack 10
O Ring for 10ml Adaptor (12pc) for use with Bioruptor & Bioruptor next gen P-10
Adaptors for 15ml tube (6pc) + Gear plate. Available for Corning & Falcon O Ring for 15ml Adaptor (6pc) for use with Bioruptor & Bioruptor next gen UCD-pack 15
O Ring for 15ml Adaptor (6pc) for use with Bioruptor & Bioruptor next gen P-10-A
Adaptors for 50ml tube (3pc) + Gear plate. Available for Corning , Falcon & Nalgene for use with Bioruptor & Bioruptor next gen UCD-pack 50
O Ring for 50ml Nalgene Adaptor (3pc) for use with Bioruptor & Bioruptor next gen P-22-A
O Ring for 50ml Corning & Falcon Adaptor (3pc) for use with Bioruptor & Bioruptor next gen P-22-B

Disposables

1.5ml Micro Tube TPX (50pc) M-50050
1.5ml Micro Tube TPX (1000pc) M-50001
10ml Tube (100pc) AS-100
10ml Tube (500pc) AS-500
15ml Tube TPX (50pc) M-UN-15
50ml Tube Nalgene (10pc) 3105-0050
50ml Glass tube BioAcc-50-GL

Diagenode Bioruptor Twin Sonicator

Bioruptor uses a unique system to uniformly process multiple samples simultaneously in sealed tubes of 0.5ml to 50ml capacity

Advantages

  • Sonicate up to 24 samples simultaneously

  • Validated from DNA & Chromatin shearing

  • Robust & reproducible results

  • Program your sonication protocol with an accurate digital timer

  • Sealed tube sonication (no contamination)

Specification

Product Codes

UCD-400TM / UCD-400TO
Ultrasonic wave frequency 20kHz
Ultrasonic wave output power 160, 200, 320W (switchable)
Power supply 230V, 50/60Hz, 2.1A
Control unit dimensions 150(W) x 300(D) x 195(H) mm
Sonication Unit dimensions 350(W) x 260(D) x 150(H) mm
Noise reduction box dimensions 200(W) x 260(D) x 360(H) mm
Waterbath volume 800cc
Reset timer Max 15min. Digital
Multitimer On Cycle 0-60 sec. or min.
Off Cycle 0-60 sec. or min.
Attachment unit Available for 0.5 - 1.5 -10 - 15 & 50ml tubes
Number of samples to be processed simultaneously

0.5 ml

1.5 ml

10 ml

15ml

50 ml

24

12

12

12

6
Total weight 30Kg

Accessories

2x Attachment for 0.5ml Micro Tube + 2x Gear plate for use with Twin Bioruptor TWI-pack 0.5
2x Attachment for 1.5ml Micro Tube + 2x Gear plate for use with Twin Bioruptor TWI-pack 1.5
2x Adaptors for 10ml tube (6pc) +2x Gear plate for use with Twin Bioruptor TWI-pack 10
O Ring for 10ml Adaptor (12pc) for use with Twin Bioruptor P-10
2x Adaptors for 15ml tube (6pc) + 2x Gear plate. Available for Corning & Falcon for use with Twin Bioruptor TWI-pack 15
O Ring for 15ml Adaptor (6pc)for use with Twin Bioruptor P-10-A
2x Adaptors for 50ml tube (3pc) + 2x Gear plate. Available for Corning , Falcon & Nalgene for use with Twin Bioruptor TWI-pack 50
O Ring for 50ml Nalgene Adaptor (3pc)for use with Twin Bioruptor P-22-A
O Ring for 50ml Corning & Falcon Adaptor (3pc) for use with Twin Bioruptor P-22-B

Disposables

1.5ml Micro Tube TPX (50pc) M-50050
1.5ml Micro Tube TPX (1000pc) M-50001
10ml Tube (100pc) AS-100
10ml Tube (500pc) AS-500
15ml Tube TPX (50pc) M-UN-15
50ml Tube Nalgene (10pc) 3105-0050
50ml Glass tube BioAcc-50-GL

Diagenode Bioruptor Water Bath

This water cooling system allows for continous cooling of the Bioruptor® waterbath. An additional regulating valve (Valve kit) ensures that water will only be replaced during the off cycle to avoid any interference between water flow and the sonication process.

 

Technical Information

Model: BioAcc-cool
Reservoir Capacity: 6 Litres
Temperature Range: -20 to 200°C
Temperature Stability: ± 0.01°C
Controller / RS232: Advanced Digital/Yes
Readout: Graphic LCD
Readout Accuracy: +/- 0.25°C
Temperature Readout: C or F
Pump Type: Pressure/Suction
Pressure Flow Rate: User-adjustable; 30 (60Hz), 22 (50Hz) lpm max
Suction Flow Rate: User-adjustable; 22 (60Hz), 15 (50Hz) lpm max
Pump Inlet and Outlet: 1/4 in. FPT Rear Discharge
Cooling Capacity at 20°C: 200W
Cooling Capacity at 0°C: 140W
Cooling Capacity at -10°C: 100W
Over-Temperature Cutoff: Adjustable
Low-Liquid Cutoff: Yes
Heater: 1100W
Input Voltage: 120 / 240V
Input Current: 12A
Input Frequency: 60hz
Working Access (L x W x D): 139.7 x 132.1 x 139.7mm
Overall Dimensions (L x W x D): 400 x 201 x 571.5mm
Weight: 31.75kg


Ordering Information

Part Code Description
BioAcc-cool Water cooler for use with Bioruptor (OPTIONAL)
CONN-7D1 Water cooler connectors for use with Bioruptor and optional water cooler. Required for UCD-200 models only
VB-100-0001 Valve kit required for use with model UCD-300 only and optional water cooler. This kit is required and benefits by producing more reproducible results
VB-101-0001 Valve kit required for use with model UCD-400 only and optional water cooler. This kit is required and benefits by producing more reproducible results
TWI-pump Peristaltic pump for use with Bioruptor Twin and optional cooler system

 

Diagenode Bioruptor Sonicator XL

Bioruptor uses a unique system to uniformly process multiple samples simultaneously in sealed tubes of 0.5ml to 50ml capacity

  • Up to 48 tubes simultaneously

  • Digital Timer

  • Metal noise reduction box

Advantages

  • Better reproducibility

  • Higher throughput

  • Validated protocols

  • Hundreds of publications

Applications for Bioruptor XL

  • Cleavage

  • Catalysis

  • Sonochemistry

  • Emulsification

  • Extraction

  • Dissolution

  • Disaggregation

  • Homogenization

  • Mixing

  • Synthesis

  • Cell lysing

  • Microencapsulation

  • Hydrolization

  • Degassing

  • Cleaning

Specification

Product Codes

XL-2006TM / XL-2006FT / XL-2006SL / XL-2006TO / XL-2006RS / XL-2006WS
Ultrasonic wave frequency 20kHz
Ultrasonic wave output power 130, 200, 250, 300W (switchable)
Power supply 240V, 50/60Hz, 3.2A
Transformer 220/100V dimensions Internal
Control unit dimensions 400(W) x 260(D) x 160(H)mm
Sonication Unit dimensions 320(W) x 180(D) x 280(H)mm
Noise reduction box dimensions 400(W) x 300(D) x 520(H)mm
Waterbath volume 1800cc
Reset timer Max 15min. Digital
Multitimer On Cycle 0-99 sec. or min.
Off Cycle 0-99 sec. or min.
Attachment unit Available for 0.5 - 1.5 -10 - 15 & 50ml tubes
Number of samples to be processed simultaneously

0.5 ml

1.5 ml

10 ml

15ml

50 ml

48

24

24

24

12
Total weight 32.5Kg

Accessories

Attachment for 0.5ml Micro Tube + Gear plate (48 tubes simultaneously) for use with Biroruptor xl XL-pack 0.5
Attachment for 1.5ml Micro Tube + Gear plate (24 tubes simultaneously) for use with Biroruptor xl XL-pack 1.5
Adaptors for 10ml tube (24pc) + Gear plate (24 tubes simultaneously) for use with Biroruptor xl XL-pack 10
O Ring for 10ml Adaptor (12pc) for use with Biroruptor xl P-10
Adaptors for 15ml tube (24pc) + Gear plate. (24 tubes simultaneously) Available for Corning & Falcon for use with Biroruptor xl XL-pack 15
O Ring for 15ml Adaptor (6pc) for use with Biroruptor xl P-10-A
Adaptors for 50ml tube (12pc) + Gear plate. (12 tubes simultaneously) Available for Corning , Falcon & Nalgene for use with Biroruptor xl XL-pack 50
O Ring for 50ml Nalgene Adaptor (3pc) for use with Biroruptor xl P-22-A
O Ring for 50ml Corning & Falcon Adaptor (3pc) for use with Biroruptor xl P-22-B

Disposables

1.5ml Micro Tube TPX (50pc) M-50050
1.5ml Micro Tube TPX (1000pc) M-50001
10ml Tube (100pc) AS-100
10ml Tube (500pc) AS-500
15ml Tube TPX (50pc) M-UN-15
50ml Tube Nalgene (10pc) 3105-0050
50ml Glass tube BioAcc-50-GL

Diagenode Bioruptor Next Gen Sonicator UCD-300

Bioruptor uses a unique system to uniformly process multiple samples simultaneously in sealed tubes of 0.5ml to 50ml capacity

Advantages

  • Better reproducibility

  • Higher throughput

  • Validated protocols

  • Hundreds of publications

Applications for Bioruptor

  • Shearing (Chromatin & DNA)

  • Cleavage

  • Catalysis

  • Sonochemistry

  • Emulsification

  • Extraction

  • Dissolution

  • Disaggregation

  • Homogenization

  • Mixing

  • Synthesis

  • Cell lysing

  • Microencapsulation

  • Hydrolization

  • Degassing

  • Cleaning

Specification

Product N°

UCD-300TM /UCD-300FT / UCD-300TO

Ultrasonic wave frequency

20kHz

Ultrasonic wave output power

160, 320W (switchable)

Power supply

100V, 50/60Hz, 4.2A

Control unit dimensions

150(W) x 300(D) x 195(H) mm

Sonication Unit dimensions

350(W) x 260(D) x 150(H) mm

Noise reduction box dimensions

35(W) x 30(D) x 52(H) mm

Waterbath volume

800cc

Digital timer

Total and Interval timer

Attachment unit

Available for 0.5 - 1.5 -10 - 15 & 50ml tubes

Number of samples to be processed simultaneously

0.5 ml

1.5 ml

10 ml

15ml

50 ml

12

6

6

6

3

Total weight

30Kg

Accessories

Soundproof Box BioBox-200 for use with Bioruptor & Bioruptor next gen UCD-200
Attachment for 0.5ml Micro Tube + Gear plate for use with Bioruptor & Bioruptor next gen UCD-pack 0.5
Attachment for 1.5ml Micro Tube + Gear plate for use with Bioruptor & Bioruptor next gen UCD-pack 1.5
Adaptors for 10ml tube (6pc) + Gear plate for use with Bioruptor & Bioruptor next gen UCD-pack 10
O Ring for 10ml Adaptor (12pc) for use with Bioruptor & Bioruptor next gen P-10
Adaptors for 15ml tube (6pc) + Gear plate. Available for Corning & Falcon O Ring for 15ml Adaptor (6pc) for use with Bioruptor & Bioruptor next gen UCD-pack 15
O Ring for 15ml Adaptor (6pc) for use with Bioruptor & Bioruptor next gen P-10-A
Adaptors for 50ml tube (3pc) + Gear plate. Available for Corning , Falcon & Nalgene for use with Bioruptor & Bioruptor next gen UCD-pack 50
O Ring for 50ml Nalgene Adaptor (3pc) for use with Bioruptor & Bioruptor next gen P-22-A
O Ring for 50ml Corning & Falcon Adaptor (3pc) for use with Bioruptor & Bioruptor next gen P-22-B

Disposables

1.5ml Micro Tube TPX (50pc) M-50050
1.5ml Micro Tube TPX (1000pc) M-50001
10ml Tube (100pc) AS-100
10ml Tube (500pc) AS-500
15ml Tube TPX (50pc) M-UN-15
50ml Tube Nalgene (10pc) 3105-0050
50ml Glass tube BioAcc-50-GL

 

GET IN TOUCH

Address Wolflabs,
Colenso House,
1 Deans Lane,
Pocklington,
YORK,
YO42 2PX

Telephone 01759 301142

Email Contact Us

WOLFLABS PROUDLY SUPPORT
WOLFLABS ARE A LIVING WAGE EMPLOYER
WOLFLABS ARE CARBON NEUTRAL
All Rights Reserved. Registered in England and Wales Registration No. 03011929 VAT Registration No. 630 9368 34. ISO 9001 & ISO 14001